| Date | Location | Result | |
| 03-21-10 | Lawrence, Kan. (Allen Fieldhouse) | Kansas 71, Creighton 68 | Box score |
| 03-19-10 | Omaha, Neb. (D.J. Sokol Arena) | Creighton 76, Stephen F. Austin 65 | Box score |
| 03-14-10 | St. Charles, Mo. (The Family Arena) | Northern Iowa 54, Creighton 53 | Box score |
| 03-13-10 | St. Charles, Mo. (The Family Arena) | Creighton 76, Wichita State 59 | Box score |
| 03-12-10 | St. Charles, Mo. (The Family Arena) | Creighton 65, Drake 62 | Box score |
| 03-06-10 | Omaha, Neb. (D.J. Sokol Arena) | Creighton 66, Indiana State 53 | Box score |
| 03-04-10 | Omaha, Neb. (D.J. Sokol Arena) | Creighton 60, Illinois State 57 | Box score |
| 02-26-10 | Des Moines, Iowa (Knapp Center) | Creighton 77, Drake 57 | Box score |
| 02-21-10 | Cedar Falls, Iowa (McLeod Center) | Northern Iowa 73, Creighton 57 | Box score |
| 02-19-10 | East Peoria, Ill. (Lorene Ramsey Gym) | Bradley 72, Creighton 62 | Box score |
| 02-13-10 | Omaha, Neb. (D.J. Sokol Arena) | Creighton 42, Evansville 41 | Box score |
| 02-11-10 | Omaha, Neb. (D.J. Sokol Arena) | Creighton 63, Southern Illinois 41 | Box score |
| 02-07-10 | Wichita, Kan. (Charles Koch Arena) | Creighton 58, Wichita State 48 | Box score |
| 02-05-10 | Springfield, Mo. (JQH Arena) | Missouri State 70, Creighton 64 | Box score |
| 01-29-10 | Omaha, Neb. (D.J. Sokol Arena) | Creighton 74, Drake 61 | Box score |
| 01-24-10 | Omaha, Neb. (D.J. Sokol Arena) | Creighton 62, Northern Iowa 58 | Box score |
| 01-22-10 | Omaha, Neb. (D.J. Sokol Arena) | Bradley 63, Creighton 57 | Box score |
| 01-16-10 | Carbondale, Ill. (SIU Arena) | Creighton 84, Southern Illinois 62 | Box score |
| 01-14-10 | Evansville, Ind. (Roberts Stadium) | Creighton 63, Evansville 37 | Box score |
| 01-09-10 | Omaha, Neb. (D.J. Sokol Arena) | Missouri State 82, Creighton 67 | Box score |
| 01-07-10 | Omaha, Neb. (D.J. Sokol Arena) | Creighton 89, Wichita State 48 | Box score |
| 01-02-10 | Normal, Ill. (Redbird Arena) | Creighton 69, Illinois State 44 | Box score |
| 12-31-09 | Terre Haute, Ind. (Hulman Center) | Creighton 55, Indiana State 44 | Box score |
| 12-20-09 | Omaha, Neb. (D.J Sokol Arena) | #15 Oklahoma 67, Creighton 58 | Box score |
| 12-13-09 | Lawrence, Kan. (Allen Fieldhouse) | #23 Kansas 77, Creighton 56 | Box score |
| 12-09-09 | Lincoln, Neb. (Devaney Sports Center) | #24 Nebraska 69, Creighton 56 | Box score |
| 12-04-09 | Omaha, Neb. (D.J. Sokol Arena) | Creighton 69, Saint Louis 58 | Box score |
| 11-27-09 | Davis, Calif. (The Pavilion) | Creighton 63, UC Davis 61 | Box score |
| 11-23-09 | Omaha, Neb. (D.J. Sokol Arena) | Creighton 63, Kansas State 54 | Box score |
| 11-19-09 | Milwaukee, Wis. (Al McGuire Center) | Marquette 66, Creighton 59 | Box score |
| 11-15-09 | Omaha, Neb. (D.J. Sokol Arena) | Creighton 77, Davidson 58 | Box score |
| 11-13-09 | Omaha, Neb. (D.J. Sokol Arena) | Creighton 77, Arkansas State 54 | Box score |