With the win the Jays collect their 20th win of the season to go to 20-6 overall and 12-3 in the Missouri Valley Conference (MVC). Bradley, meanwhile, fell to 11-14 on the season and 5-9 in MVC play.
It is the seventh time in head coach Jim Flanery's 11 seasons that Creighton has reached the 20-win plateau. In the Jays' previous 29 seasons it had been done just eight times.
Kamphaus set the tone for the Jays in the opening five minutes by dropping in Creighton's first nine points to force Bradley out of its five-guard lineup that started the game. Kamphaus' play opened up the outside for junior Jordan Garrison to drain the Jays' first three and extend Creighton's lead to 12-7 with 14:42 to play.
Up 12-9 moments later, Nelson went to work on the block. Nelson dropped interior buckets around a layup by Garrison to push the Creighton advantage to 18-9.
The Jays went on to score 24 points in the paint in the opening period to take a 44-28 lead into halftime.
The second half started just as the first period had, with Kamphaus and Nelson leading Creighton on an 11-3 run. Up 55-31 the Jays never looked back allowing Bradley no closer than 15 points the rest of the way.
Nelson led Creighton with 18 points, while Kamphaus finished with career-highs in points (17) and blocks (4). Three other Jays finished in double-figures as senior Ally Jensen had 15 points, while Garrison posted 11 and freshman Marissa Janning delivered 10.
Bradley had three players finish in double digits led by a game-high 19 points from Michelle Young. Katie Yohn chipped in 15 points and Brooke Bisping finished with 11.
The NCAA leader, Creighton dropped in 13 three-point field goals in the contest 13-38 (46.3%).
The Jays face travel partner Drake in their lone game next week as Creighton hosts the Bulldogs on Sunday, March 3 at 2:05 p.m.